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Article

Investigating the interference of single nucleotide polymorphisms with miRNA mediated gene regulation in pancreatic ductal adenocarcinoma: An in silico approach.

Gene - 20 Apr 2022

Mukherjee Moumita, Ghosh Satyajit, Goswami Srikanta

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a strong genetic component and single nucleotide polymorphisms (SNPs) in key genes have been found to modulate the susceptibility of the individuals to the disease. SNPs in 3'-UTR of the target genes or in miRNA seed region has gained much importance as this may lead to impairment of miRNA-mRNA interaction. Not much information about this phenomenon is...

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PMID: 35121024
DOI: 10.1016/j.gene.2022.146259

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