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Rs12039395 Variant Influences the Expression of hsa-miR-181a-5p and PTEN Toward Colorectal Cancer Risk.

Digestive diseases and sciences - 1 Sept 2024

El-Korany Wael A, Zahran Walid E, Alm El-Din Mohamed A, Al-Shenawy Hanan A, Soliman Ahmed F

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes could alter miRNA expression levels or processing and, thus, may contribute to colorectal cancer (CRC) development. Therefore, this study aimed to examine whether the MIR181A1 genomic sequence possesses SNPs that can affect the expression of hsa-miR-181a-5p and, subsequently, impact its targets and associate with CRC risk. METHODS: The...

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Aged
Case-Control Studies
Colorectal Neoplasms
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

PTEN Phosphohydrolase

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PMID: 38940971
DOI: 10.1007/s10620-024-08517-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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