Genome-Wide DNA Copy Number Analysis of Acute Lymphoblastic Leukemia Identifies New Genetic Markers Associated with Clinical Outcome.

doi:10.1371/journal.pone.0148972

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Article

Genome-Wide DNA Copy Number Analysis of Acute Lymphoblastic Leukemia Identifies New Genetic Markers Associated with Clinical Outcome.

PloS one - 1 Jan 2016

Forero-Castro Maribel, Robledo Cristina, Benito Rocío, Abáigar María, África Martín Ana, Arefi Maryam, Fuster José Luis, de Las Heras Natalia, Rodríguez Juan N, Quintero Jonathan, Riesco Susana, Hermosín Lourdes, de la Fuente Ignacio, Recio Isabel, Ribera Jordi, Labrador Jorge, Alonso José M, Olivier Carmen, Sierra Magdalena, Megido Marta, Corchete-Sánchez Luis A, Ciudad Pizarro Juana, García Juan Luis, Ribera José M, Hernández-Rivas Jesús M

Abstract excerpt

UNLABELLED: Identifying additional genetic alterations associated with poor prognosis in acute lymphoblastic leukemia (ALL) is still a challenge. AIMS: To characterize the presence of additional DNA copy number alterations (CNAs) in children and adults with ALL by whole-genome oligonucleotide array (aCGH) analysis, and to identify their associations with clinical features and outcome. Array-CGH was carried out in...

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PMID: 26872047
DOI: 10.1371/journal.pone.0148972
PMCID: PMC4752220

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