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Article

High rates of submicroscopic aberrations in karyotypically normal acute lymphoblastic leukemia

29 Jun 2015

Abstract excerpt

BACKGROUND: Acute lymphoblastic leukemia (ALL) is not a single uniform disease. It consists of several subgroups with different cytogenetic and molecular genetic aberrations, clinical presentations and outcomes. Banding cytogenetics plays a pivotal role in the detection of recurrent chromosomal rearrangements and is the starting point of genetic analysis in ALL, still. Nowadays, molecular (cyto)genetic tools...

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PMID: 26136832
DOI: 10.1186/s13039-015-0153-4

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