Article
Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer.
Oncotarget - 22 Mar 2016
Strickland Kyle C, Howitt Brooke E, Shukla Sachet A, Rodig Scott, Ritterhouse Lauren L, Liu Joyce F, Garber Judy E, Chowdhury Dipanjan, Wu Catherine J, D'Andrea Alan D, Matulonis Ursula A, Konstantinopoulos Panagiotis A
Abstract excerpt
Immune checkpoint inhibitors (e.g., anti-PD-1 and anti-PD-L1 antibodies) have demonstrated remarkable efficacy against hypermutated cancers such as melanomas and lung carcinomas. One explanation for this effect is that hypermutated lesions harbor more tumor-specific neoantigens that stimulate recruitment of an increased number of tumor-infiltrating lymphocytes (TILs), which is counterbalanced by overexpression of...
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