Article

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

2016-11-28

Abstract excerpt

<h4>Background</h4> Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due to increased neoantigen expression. Many chemotherapies including platinum compounds are known to be mutagenic, but the impact of standard treatment protocols on mutational burden and resulting neoantigen expression in most human...

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Literature Corpus work: 58d6db7b-a48f-54c0-a5f2-f59b7f023db3
DOI: 10.1101/090134

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