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Article

Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma.

Oncotarget - 19 Apr 2016

Wang Na, Kjellin Hanna, Sofiadis Anastasios, Fotouhi Omid, Juhlin C Christofer, Bäckdahl Martin, Zedenius Jan, Xu Dawei, Lehtiö Janne, Larsson Catharina

Abstract excerpt

Medullary thyroid carcinomas (MTCs) exhibit telomerase activation in strong association with shorter patient survival. To understand the background of telomerase activation we quantified TERT copy numbers and TERT promoter methylation in 42 MTCs and normal thyroid references. Gain of TERT was demonstrated by quantitative PCR in 5/39 sporadic MTC. Increased methylation index (MetI) for CpG methylation at the TERT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26870890
DOI: 10.18632/oncotarget.7237
PMCID: PMC5008288

Genes

TERT
XRCC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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