Article
Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations.
Scientific reports - 9 Feb 2017
Oczko-Wojciechowska Malgorzata, Swierniak Michal, Krajewska Jolanta, Kowalska Malgorzata, Kowal Monika, Stokowy Tomasz, Wojtas Bartosz, Rusinek Dagmara, Pawlaczek Agnieszka, Czarniecka Agnieszka, Szpak-Ulczok Sylwia, Gawlik Tomasz, Chmielik Ewa, Tyszkiewicz Tomasz, Nikiel Barbara, Lange Dariusz, Jarzab Michal, Wiench Malgorzata, Jarzab Barbara
Abstract excerpt
Medullary thyroid cancer (MTC) can be caused by germline mutations of the RET proto-oncogene or occurs as a sporadic form. It is well known that RET mutations affecting the cysteine-rich region of the protein (MEN2A-like mutations) are correlated with different phenotypes than those in the kinase domain (MEN2B-like mutations). Our aim was to analyse the whole-gene expression profile of MTC with regard to the type...
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