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Article

Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis.

Molecular oncology - 1 Feb 2016

Bjaanæs Maria Moksnes, Fleischer Thomas, Halvorsen Ann Rita, Daunay Antoine, Busato Florence, Solberg Steinar, Jørgensen Lars, Kure Elin, Edvardsen Hege, Børresen-Dale Anne-Lise, Brustugun Odd Terje, Tost Jörg, Kristensen Vessela, Helland Åslaug

Abstract excerpt

BACKGROUND: DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells. Lung cancer patients have in general a poor prognosis, and a deeper insight into the epigenetic landscape in lung adenocarcinoma tumors and its prognostic implications is needed. RESULTS: We determined whole-genome DNA methylation profiles of 164 fresh frozen lung...

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Identifiers

PMID: 26601720
DOI: 10.1016/j.molonc.2015.10.021
PMCID: PMC5528958

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EGFR
KRAS

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Source receipt: pubmed, retrieved 7 Sept 2026.

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