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Article

Increased phosphorylation of ERK1/2 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced lung adenocarcinoma.

Medical molecular morphology - 1 Jun 2016

Tsujino Ichiro, Nakanishi Yoko, Hiranuma Hisato, Shimizu Tetsuo, Hirotani Yukari, Ohni Sumie, Ouchi Yasushi, Takahashi Noriaki, Nemoto Norimichi, Hashimoto Shu

Abstract excerpt

Constitutive activation of extracellular signal-regulated kinase (ERK)1/2 pathway, that is activated by various stimuli including growth factors and oncogenic driver mutations, is observed in various cancers. However, the difference of the activated levels of the pathway is still unclear in clinical significances. The aim of this study was to investigate the effect of different ERK1/2 pathway activation, assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26705127
DOI: 10.1007/s00795-015-0130-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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