Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas.

Abstract excerpt

In the resected lung, additional small lesions are occasionally found incidentally, and include the full spectrum of preinvasive to invasive lesions under the current putative schema of the sequential development of lung cancer. In this study, we examined EGFR and KRAS gene mutations in 119 synchronous pulmonary lesions, including 40 precursor lesions (atypical adenomatous hyperplasia, AAH), 26 carcinomas in situ...

Topics

• Adenocarcinoma
• DNA Mutational Analysis
• Disease Progression
• ErbB Receptors
• Humans
• Hyperplasia
• Lung Neoplasms
• Mutation
• Neoplasms, Multiple Primary
• Precancerous Conditions