Article
Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2016
Bi Mark, Zhao Siming, Said Jonathan W, Merino Maria J, Adeniran Adebowale J, Xie Zuoquan, Nawaf Cayce B, Choi Jaehyuk, Belldegrun Arie S, Pantuck Allan J, Kluger Harriet M, Bilgüvar Kaya, Lifton Richard P, Shuch Brian
Abstract excerpt
The presence of sarcomatoid features in clear cell renal cell carcinoma (ccRCC) confers a poor prognosis and is of unknown pathogenesis. We performed exome sequencing of matched normal-carcinomatous-sarcomatoid specimens from 21 subjects. Two tumors had hypermutation consistent with mismatch repair deficiency. In the remainder, sarcomatoid and carcinomatous elements shared 42% of somatic single-nucleotide...
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