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Article

Molecular underpinnings of dedifferentiation and aggressiveness in chromophobe renal cell carcinoma.

JCI insight - 18 Apr 2024

Kapur Payal, Zhong Hua, Le Daniel, Mukhopadhyay Ratna, Miyata Jeffrey, Carrillo Deyssy, Rakheja Dinesh, Rajaram Satwik, Durinck Steffen, Modrusan Zora, Brugarolas James

Abstract excerpt

Sarcomatoid dedifferentiation is common to multiple renal cell carcinoma (RCC) subtypes, including chromophobe RCC (ChRCC), and is associated with increased aggressiveness, resistance to targeted therapies, and heightened sensitivity to immunotherapy. To study ChRCC dedifferentiation, we performed multiregion integrated paired pathological and genomic analyses. Interestingly, ChRCC dedifferentiates not only into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38775158
DOI: 10.1172/jci.insight.176743
PMCID: PMC11141915

Genes

PTEN
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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