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Article

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.

Heart rhythm - 1 Dec 2012

DeGrande Sean, Nixon Derek, Koval Olha, Curran Jerald W, Wright Patrick, Wang Qiongling, Kashef Farshid, Chiang David, Li Na, Wehrens Xander H T, Anderson Mark E, Hund Thomas J, Mohler Peter J

Abstract excerpt

BACKGROUND: Cardiovascular disease is a leading cause of death worldwide. Arrhythmias are associated with significant morbidity and mortality related to cardiovascular disease. Recent work illustrates that many cardiac arrhythmias are initiated by a pathologic imbalance between kinase and phosphatase activities in excitable cardiomyocytes. OBJECTIVE: To test the relationship between myocyte kinase/phosphatase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23059182
DOI: 10.1016/j.hrthm.2012.08.026
PMCID: PMC3630478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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