Article
Next generation sequencing of DNA-launched Chikungunya vaccine virus.
Virology - 1 Mar 2016
Hidajat Rachmat, Nickols Brian, Forrester Naomi, Tretyakova Irina, Weaver Scott, Pushko Peter
Abstract excerpt
Chikungunya virus (CHIKV) represents a pandemic threat with no approved vaccine available. Recently, we described a novel vaccination strategy based on iDNA® infectious clone designed to launch a live-attenuated CHIKV vaccine from plasmid DNA in vitro or in vivo. As a proof of concept, we prepared iDNA plasmid pCHIKV-7 encoding the full-length cDNA of the 181/25 vaccine. The DNA-launched CHIKV-7 virus was...
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