Chikungunya Virus Vaccine Candidates with Decreased Mutational Robustness Are AttenuatedIn Vivoand Have Compromised Transmissibility

Abstract excerpt

Chikungunya fever is a debilitating disease that causes severe pain to the joints, which can compromise the patient's lifestyle for several months and even in some grave cases lead to death. The etiological agent is chikungunya virus, an alphavirus transmitted by mosquito bite. Currently, there are no approved vaccines or treatments against the disease. In our research, we developed novel live attenuated vaccine...

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• Insect symbiosis and bacterial influences
• Mosquito-borne diseases and control
• Viral Infections and Vectors