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Live-attenuated CHIKV vaccine with rearranged genome replicates in vitro and induces immune response in mice

22 Apr 2024

Abstract excerpt

Chikungunya fever virus (CHIKV) is a mosquito-borne alphavirus that causes wide-spread human infections and epidemics in Asia, Africa and recently, in the Americas. CHIKV is considered a priority pathogen by CEPI and WHO. Despite recent approval of a live-attenuated CHIKV vaccine, development of additional vaccines is warranted due to the worldwide outbreaks of CHIKV. Previously, we developed immunization DNA...

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PMID: 38648230
DOI: 10.1371/journal.pntd.0012120

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