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Article

Infectious RNA vaccine protects mice against chikungunya virus infection.

Scientific reports - 3 Dec 2020

Szurgot Inga, Ljungberg Karl, Kümmerer Beate M, Liljeström Peter

Abstract excerpt

We describe a novel vaccine platform that can generate protective immunity to chikungunya virus (CHIKV) in C57BL/6J mice after a single immunization by employing an infectious RNA (iRNA), which upon introduction into a host cell launches an infectious attenuated virus. We and others have previously reported that an engineered deletion of 183 nucleotides in the nsP3 gene attenuates chikungunya virus (CHIKV) and...

Topics

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Antibodies, Neutralizing
Chikungunya Fever
Chikungunya virus
Immunogenicity, Vaccine
Injections, Intramuscular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vaccines, Attenuated

Vaccines, Synthetic

Viral Nonstructural Proteins

Source

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Identifiers

PMID: 33273501
DOI: 10.1038/s41598-020-78009-7
PMCID: PMC7712826

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