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Article

Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.

Blood cells, molecules & diseases - 1 Mar 2016

Noronha Elda Pereira, Andrade Francianne Gomes, Zampier Carolina, de Andrade Camilla F C G, Terra-Granado Eugênia, Pombo-de-Oliveira Maria S

Abstract excerpt

With the combination of immunophenotyping and molecular tests, it is still a challenge to identify the characteristics of T cell acute lymphoblastic leukemia (T-ALL) associated with distinct outcomes. This study tests the possible correlation of cellular expression of CD135 and CD117 with somatic gene mutations in T-ALL. One hundred sixty-two samples were tested, including 143 at diagnosis, 15 from...

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Share to Basic Helix-Loop-Helix Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Share to T-Cell Acute Lymphocytic Leukemia Protein 1

Source

Identifiers

PMID: 26852660
DOI: 10.1016/j.bcmd.2015.12.003

Genes

FLT3
TLX3
STIL
TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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