Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression on outcome.

doi:10.3324/haematol.13291

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Article

Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression on outcome.

Haematologica - 1 Nov 2008

Ballerini Paola, Landman-Parker Judith, Cayuela Jean Michel, Asnafi Vahid, Labopin Myriam, Gandemer Virginie, Perel Yves, Michel Gérard, Leblanc Thierry, Schmitt Claudine, Fasola Sylvie, Hagemejier Anne, Sigaux François, Auclerc Marie Françoise, Douay Luc, Leverger Guy, Baruchel André

Abstract excerpt

BACKGROUND: The prognostic value of the ectopic activation of TLX3 gene expression, a major oncogenetic event associated with pediatric T-cell acute lymphoblastic leukemia, is controversial. Likewise, the frequency and the prognostic significance in pediatric T-cell acute lymphoblastic leukemia of the newly characterized NUP214-ABL1 fusion transcript is not yet clear. DESIGN AND METHODS: Two hundred children with...

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PMID: 18835836
DOI: 10.3324/haematol.13291

Genes

TLX3
ABL1
TLX1

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