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Activating FLT3 mutations in CD117/KIT+ T-cell acute lymphoblastic leukemias

29 Mar 2004

Abstract excerpt

Activating FLT3 mutations are the most common genetic aberrations in acute myeloid leukemia (AML), resulting in the constitutive activation of this receptor tyrosine kinase (RTK), but such mutations are rarely found in acute lymphoblastic leukemia (ALL). Here we describe a unique subset of de novo adult T-cell ALL (T-ALL) cases that coexpress CD117/KIT and cytoplasmic CD3 (CD117/KIT(+) ALL). Activating mutations...

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PMID: 15044257
DOI: 10.1182/blood-2004-01-0168

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