Article
Genome-wide association study of serum iron phenotypes in premenopausal women of European descent.
Blood cells, molecules & diseases - 1 Mar 2016
Koller Daniel L, Imel Erik A, Lai Dongbing, Padgett Leah R, Acton Dena, Gray Amie, Peacock Munro, Econs Michael J, Foroud Tatiana
Abstract excerpt
A genome-wide association study was performed on 1130 premenopausal women to detect common variants associated with three serum iron-related phenotypes. Total iron binding capacity was strongly associated (p=10(-14)) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p=4×10(-7)), which encodes the human hemochromatosis gene. Association was also...
Topics
- Adult
- Chromosomes, Human, Pair 6
- Female
- Gene Expression
- Genome-Wide Association Study
- Hemochromatosis
- Hemochromatosis Protein
- Histocompatibility Antigens Class I
- Humans
- Iron
- Membrane Proteins
- Middle Aged
- Phenotype