Article
A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study.
Clinical genetics - 1 Jun 2007
Acton R T, Snively B M, Barton J C, McLaren C E, Adams P C, Rich S S, Eckfeldt J H, Press R D, Sholinsky P, Leiendecker-Foster C, McLaren G D, Speechley M R, Harris E L, Dawkins F W, Gordeuk V R
Abstract excerpt
Iron overload phenotypes in persons with and without hemochromatosis are variable. To investigate this further, probands with hemochromatosis or evidence of elevated iron stores and their family members were recruited for a genome-wide linkage scan to identify potential quantitative trait loci (QTL) that contribute to variation in transferrin saturation (TS), unsaturated iron-binding capacity (UIBC), and serum...
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