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Article

Gene set analysis using sufficient dimension reduction.

BMC bioinformatics - 6 Feb 2016

Hsueh Huey-Miin, Tsai Chen-An

Abstract excerpt

BACKGROUND: Gene set analysis (GSA) aims to evaluate the association between the expression of biological pathways, or a priori defined gene sets, and a particular phenotype. Numerous GSA methods have been proposed to assess the enrichment of sets of genes. However, most methods are developed with respect to a specific alternative scenario, such as a differential mean pattern or a differential coexpression....

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PMID: 26852017
DOI: 10.1186/s12859-016-0928-6
PMCID: PMC4744442

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