Article
Gene-set analysis and reduction.
Briefings in bioinformatics - 1 Jan 2009
Dinu Irina, Potter John D, Mueller Thomas, Liu Qi, Adewale Adeniyi J, Jhangri Gian S, Einecke Gunilla, Famulski Konrad S, Halloran Philip, Yasui Yutaka
Abstract excerpt
Gene-set analysis aims to identify differentially expressed gene sets (pathways) by a phenotype in DNA microarray studies. We review here important methodological aspects of gene-set analysis and illustrate them with varying performance of several methods proposed in the literature. We emphasize the importance of distinguishing between 'self-contained' versus 'competitive' methods, following Goeman and Bühlmann....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.