Article
Comparative study of gene set enrichment methods.
BMC bioinformatics - 2 Sept 2009
Abatangelo Luca, Maglietta Rosalia, Distaso Angela, D'Addabbo Annarita, Creanza Teresa Maria, Mukherjee Sayan, Ancona Nicola
Abstract excerpt
BACKGROUND: The analysis of high-throughput gene expression data with respect to sets of genes rather than individual genes has many advantages. A variety of methods have been developed for assessing the enrichment of sets of genes with respect to differential expression. In this paper we provide a comparative study of four of these methods: Fisher's exact test, Gene Set Enrichment Analysis (GSEA), Random-Sets...
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