Article
Linear combination test for gene set analysis of a continuous phenotype.
BMC bioinformatics - 1 Jul 2013
Dinu Irina, Wang Xiaoming, Kelemen Linda E, Vatanpour Shabnam, Pyne Saumyadipta
Abstract excerpt
BACKGROUND: Gene set analysis (GSA) methods test the association of sets of genes with a phenotype in gene expression microarray studies. Many GSA methods have been proposed, especially methods for use with a binary phenotype. Equally, if not more importantly however, is the ability to test the enrichment of a gene signature or pathway against the continuous phenotypes which are routinely and commonly observed...
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