Differential regulation enrichment analysis via the integration of transcriptional regulatory network and gene expression data.

Abstract excerpt

MOTIVATION: Although many gene set analysis methods have been proposed to explore associations between a phenotype and a group of genes sharing common biological functions or involved in the same biological process, the underlying biological mechanisms of identified gene sets are typically unexplained. RESULTS: We propose a method called Differential Regulation-based enrichment Analysis for GENe sets (DRAGEN) to...

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