Article
Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2022
Kanagal-Shamanna Rashmi, Orazi Attilio, Hasserjian Robert P, Arber Daniel A, Reichard Kaaren, Hsi Eric D, Bagg Adam, Rogers Heesun Joyce, Geyer Julia, Darbaniyan Faezeh, Do Kim-Anh, Devins Kyle M, Pozdnyakova Olga, George Tracy I, Cin Paola Dal, Greipp Patricia T, Routbort Mark J, Patel Keyur, Garcia-Manero Guillermo, Verstovsek Srdan, Medeiros L Jeffrey, Wang Sa A, Bueso-Ramos Carlos
Abstract excerpt
Classification of myeloid neoplasms with isolated isochromosome i(17q) [17p deletion with inherent monoallelic TP53 loss plus 17q duplication] is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. The uniformly dismal outcomes warrant better understanding of this entity. We undertook a multi-institutional retrospective study of 92 adult...
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