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Article

Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2017

Yu Lijian, Kim Haesook T, Kasar Siddha, Benien Parul, Du Wei, Hoang Kevin, Aw Andrew, Tesar Bethany, Improgo Reina, Fernandes Stacey, Radhakrishnan Saranya, Klitgaard Josephine, Lee Charles, Getz Gad, Setlur Sunita R, Brown Jennifer R

Abstract excerpt

PURPOSE: Chronic lymphocytic leukemia (CLL) with 17p deletion typically progresses quickly and is refractory to most conventional therapies. However, some del(17p) patients do not progress for years, suggesting that del(17p) is not the only driving event in CLL progression. We hypothesize that other concomitant genetic abnormalities underlie the clinical heterogeneity of del(17p) CLL. EXPERIMENTAL DESIGN: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27503198
DOI: 10.1158/1078-0432.CCR-16-0594
PMCID: PMC5467311

Genes

GPS2
NOTCH1
RPS15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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