Epstein-Barr virus genetic variants are associated with multiple sclerosis.

doi:10.1212/WNL.0000000000001420

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Article

Epstein-Barr virus genetic variants are associated with multiple sclerosis.

Neurology - 31 Mar 2015

Mechelli Rosella, Manzari Caterina, Policano Claudia, Annese Anita, Picardi Ernesto, Umeton Renato, Fornasiero Arianna, D'Erchia Anna Maria, Buscarinu Maria Chiara, Agliardi Cristina, Annibali Viviana, Serafini Barbara, Rosicarelli Barbara, Romano Silvia, Angelini Daniela F, Ricigliano Vito A G, Buttari Fabio, Battistini Luca, Centonze Diego, Guerini Franca R, D'Alfonso Sandra, Pesole Graziano, Salvetti Marco, Ristori Giovanni

Abstract excerpt

OBJECTIVE: We analyzed the Epstein-Barr nuclear antigen 2 (EBNA2) gene, which contains the most variable region of the viral genome, in persons with multiple sclerosis (MS) and control subjects to verify whether virus genetic variants are involved in disease development. METHODS: A seminested PCR approach and Sanger sequencing were used to analyze EBNA2 in 53 patients and 38 matched healthy donors (HDs)....

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PMID: 25740864
DOI: 10.1212/WNL.0000000000001420
PMCID: PMC4388746

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