Article
Transgenic Expression of the Formin Protein Fhod3 Selectively in the Embryonic Heart: Role of Actin-Binding Activity of Fhod3 and Its Sarcomeric Localization during Myofibrillogenesis.
PloS one - 1 Jan 2016
Fujimoto Noriko, Kan-O Meikun, Ushijima Tomoki, Kage Yohko, Tominaga Ryuji, Sumimoto Hideki, Takeya Ryu
Abstract excerpt
Fhod3 is a cardiac member of the formin family proteins that play pivotal roles in actin filament assembly in various cellular contexts. The targeted deletion of mouse Fhod3 gene leads to defects in cardiogenesis, particularly during myofibrillogenesis, followed by lethality at embryonic day (E) 11.5. However, it remains largely unknown how Fhod3 functions during myofibrillogenesis. In this study, to assess the...
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