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Article

Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles.

The Journal of biological chemistry - 23 Oct 2009

Taniguchi Kenichiro, Takeya Ryu, Suetsugu Shiro, Kan-O Meikun, Narusawa Megumi, Shiose Akira, Tominaga Ryuji, Sumimoto Hideki

Abstract excerpt

Actin filament assembly in nonmuscle cells is regulated by the actin polymerization machinery, including the Arp2/3 complex and formins. However, little is known about the regulation of actin assembly in muscle cells, where straight actin filaments are organized into the contractile unit sarcomere. Here, we show that Fhod3, a myocardial formin that localizes to thin actin filaments in a striated pattern,...

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Identifiers

PMID: 19706596
DOI: 10.1074/jbc.M109.059303
PMCID: PMC2785617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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