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Article

GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders.

PloS one - 1 Jan 2016

Davis Kasey N, Tao Ran, Li Chao, Gao Yuan, Gondré-Lewis Marjorie C, Lipska Barbara K, Shin Joo Heon, Xie Bin, Ye Tianzhang, Weinberger Daniel R, Kleinman Joel E, Hyde Thomas M

Abstract excerpt

Genetic variation and early adverse environmental events work together to increase risk for schizophrenia. γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in adult mammalian brain, plays a major role in normal brain development, and has been strongly implicated in the pathobiology of schizophrenia. GABA synthesis is controlled by two glutamic acid decarboxylase (GAD) genes, GAD1 and GAD2, both...

Topics

Adolescent
Adult
Alternative Splicing
Child
Child, Preschool
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Glutamate Decarboxylase
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Infant, Newborn

Male

Mood Disorders

Prefrontal Cortex

RNA, Messenger

Regression Analysis

Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 26848839
DOI: 10.1371/journal.pone.0148558
PMCID: PMC4744057

Genes

GAD2
GAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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