Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders.

PloS one - 18 Sept 2009

Zhao Cunyou, Xu Zhiwen, Wang Feng, Chen Jianhuan, Ng Siu-Kin, Wong Pak-Wing, Yu Zhiliang, Pun Frank W, Ren Lihuan, Lo Wing-Sze, Tsang Shui-Ying, Xue Hong

Abstract excerpt

BACKGROUND: Non-coding single nucleotide polymorphisms (SNPs) in GABRB2, the gene for beta(2)-subunit of gamma-aminobutyric acid type A (GABA(A)) receptor, have been associated with schizophrenia (SCZ) and quantitatively correlated to mRNA expression and alternative splicing. METHODS AND FINDINGS: Expression of the Exon 10 region of GABRB2 from minigene constructs revealed this region to be an "alternative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Bipolar Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Protein Isoforms

Share to Psychotic Disorders

Share to Receptors, GABA-A

Share to Schizophrenia

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 19763268
DOI: 10.1371/journal.pone.0006977
PMCID: PMC2741204

Genes

GABRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders.PMID 19763268Read ↗

GABRB2, a key player in neuropsychiatric disorders and beyond.Semantic proximity Read ↗

Epigenetic regulation on GABRB2 isoforms expression: developmental variations and disruptions in psychotic disorders.Semantic proximity Read ↗

Relationship between GABRB2 gene polymorphisms and schizophrenia susceptibility: a case-control study and in silico analyses.Semantic proximity Read ↗

GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations.Semantic proximity Read ↗

Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor β(2) subunit.Semantic proximity Read ↗

Analysis of the effects of rare variants on splicing identifies alterations in GABAA receptor genes in autism spectrum disorder individuals.Semantic proximity Read ↗

Alternative splicing and promoter use in the human GABRA2 gene.Semantic proximity Read ↗

Identification of SNPs in human gamma aminobutyric acid A receptor gamma2 gene.Semantic proximity Read ↗

Characterization of the GABRB2-Associated Neurodevelopmental Disorders.Semantic proximity Read ↗

GABRB2 association with schizophrenia: commonalities and differences between ethnic groups and clinical subtypes.Semantic proximity Read ↗

GABBR2 mutations determine phenotype in rett syndrome and epileptic encephalopathy.Semantic proximity Read ↗

Missense variants in GABA <sub>A</sub> receptor beta2 subunit disrupt receptor biogenesis and cause loss of functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.