Article
GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations.
Biochemical Society transactions - 1 Dec 2009
Chen Jianhuan, Tsang Shui-Ying, Zhao Cun-You, Pun Frank W, Yu Zhiliang, Mei Lingling, Lo Wing-Sze, Fang Shisong, Liu Hua, Stöber Gerald, Xue Hong
Abstract excerpt
The SCZ (schizophrenia)-associated GABA(A) receptor (gamma-aminobutyric acid type A receptor) beta(2) subunit gene GABRB2 was recently associated with BPD (bipolar disorder). Although weaker than its association with SCZ, significant association of GABRB2 with BPD was found in both German and Chinese, especially for the haplotypes rs1816071-rs187269 and rs1816072-rs187269 for which the M-M variants showed higher...