GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.

doi:10.1038/mp.2017.105

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Article

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.

Molecular psychiatry - 1 Jun 2018

Tao R, Davis K N, Li C, Shin J H, Gao Y, Jaffe A E, Gondré-Lewis M C, Weinberger D R, Kleinman J E, Hyde T M

Abstract excerpt

Genetic variations and adverse environmental events in utero or shortly after birth can lead to abnormal brain development and increased risk of schizophrenia. γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian brain, plays a vital role in normal brain development. GABA synthesis is controlled by enzymes derived from two glutamic acid decarboxylase (GAD) genes, GAD1 and GAD2, both...

Topics

Adolescent
Adult
Alternative Splicing
Autopsy
Brain
Child
Child, Preschool
DNA Methylation
Female
Gene Expression
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutamate Decarboxylase

Hippocampus

Humans

Infant, Newborn

Male

Prefrontal Cortex

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28485403
DOI: 10.1038/mp.2017.105
PMCID: PMC7564279

Genes

GAD1
GAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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