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Article

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.

Molecular psychiatry - 1 Jun 2018

Tao R, Davis K N, Li C, Shin J H, Gao Y, Jaffe A E, Gondré-Lewis M C, Weinberger D R, Kleinman J E, Hyde T M

Abstract excerpt

Genetic variations and adverse environmental events in utero or shortly after birth can lead to abnormal brain development and increased risk of schizophrenia. γ-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian brain, plays a vital role in normal brain development. GABA synthesis is controlled by enzymes derived from two glutamic acid decarboxylase (GAD) genes, GAD1 and GAD2, both...

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Source

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Identifiers

PMID: 28485403
DOI: 10.1038/mp.2017.105
PMCID: PMC7564279

Genes

GAD1
GAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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