Article
Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.
BMC pregnancy and childbirth - 5 Feb 2016
Ramos Bruna Ribeiro de Andrade, Mendes Niele Dias, Tanikawa Aline Aki, Amador Marcos Antônio Trindade, dos Santos Ney Pereira Carneiro, dos Santos Sidney Emanuel Batista, Castelli Erick C, Witkin Steven S, da Silva Márcia Guimarães
Abstract excerpt
BACKGROUND: A genetic predisposition to Preterm Labor (PTL) and Preterm Premature Rupture of Membranes (PPROM) has been suggested; however the relevance of polymorphisms and ancestry to susceptibility to PTL and PPROM in different populations remains unclear. The aim of this study was to evaluate the contribution of maternal and fetal SNPs in the IL1B, IL6, IL6R, TNFA, TNFR, IL10, TLR2, TLR4, MMP9, TIMP1 and...
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