Article
SNPs and transcriptional activity of genes of innate and adaptive immunity at the maternal-fetal interface in woman with preterm labour, associated with preterm premature rupture of membranes.
Wiadomosci lekarskie (Warsaw, Poland : 1960) - 1 Jan 2020
Lyubomirskaya Ekaterina S, Kamyshnyi Alexandr M, Krut Yuriy Ya, Smiianov Vladyslav A, Fedoniuk Larisa Ya, Romanyuk Lidiya B, Kravets Natalya Ya, Mochulska Oksana M
Abstract excerpt
OBJECTIVE: The aim is to identify mRNA expression of innate (TLR2 and TLR4) and adaptive (IL1 β, IL17A, FoxP3, Tbet, Roryt) immunity in maternal-fetal interface and evaluate the contribution of SNP genes of IL1β (rs1143627), TNFα (rs1800629), IL4 (rs2243250), IL10 (rs1800896, rs1800872) and RLN2 (, ) to PTB, associated with PPROM in 26-34 weeks of gestation. PATIENTS AND METHODS: Materials and...