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Pathway analysis of genetic factors associated with spontaneous preterm birth and pre-labor preterm rupture of membranes.

PloS one - 1 Jan 2014

Capece Antonio, Vasieva Olga, Meher Shireen, Alfirevic Zarko, Alfirevic Ana

Abstract excerpt

BACKGROUND: Pre-term birth (PTB) remains the leading cause of infant mortality and morbidity. Its etiology is multifactorial, with a strong genetic component. Genetic predisposition for the two subtypes, spontaneous PTB with intact membranes (sPTB) and preterm prelabor rapture of membranes (PPROM), and differences between them, have not yet been systematically summarised. METHODS AND FINDINGS: Our literature...

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Autoimmunity
Interferon Regulatory Factor-3
PPAR gamma
Pregnancy Complications
Premature Birth

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Receptors, Estrogen

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PMID: 25264875
DOI: 10.1371/journal.pone.0108578
PMCID: PMC4181300

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ESR2
PPARG
STAT1

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