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Article

Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers.

PloS one - 17 Jan 2011

Gonzalez-Bosquet Jesus, Calcei Jacob, Wei Jun S, Garcia-Closas Montserrat, Sherman Mark E, Hewitt Stephen, Vockley Joseph, Lissowska Jolanta, Yang Hannah P, Khan Javed, Chanock Stephen

Abstract excerpt

Identification of somatic mutations in cancer is a major goal for understanding and monitoring the events related to cancer initiation and progression. High resolution melting (HRM) curve analysis represents a fast, post-PCR high-throughput method for scanning somatic sequence alterations in target genes. The aim of this study was to assess the sensitivity and specificity of HRM analysis for tumor mutation...

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Source

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Identifiers

PMID: 21264207
DOI: 10.1371/journal.pone.0014522
PMCID: PMC3022009

Genes

BRAF
EGFR
ERBB2
FGFR3
GATA3
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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