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Article

FGFR1 is a potential therapeutic target in neuroblastoma

29 Apr 2022

Abstract excerpt

Abstract Background FGFR1regulates cell–cell adhesion and extracellular matrix architecture and acts as oncogene in several cancers. Potential cancer driver mutations ofFGFR1occur in neuroblastoma (NB), a neural crest-derived pediatric tumor arising in sympathetic nervous system, but so far they have not been studied experimentally. We investigated the driver-oncogene role ofFGFR1and the implication of N546K...

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PMID: 35488346
DOI: 10.1186/s12935-022-02587-x

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