Article
Increased total homocysteine level is associated with clinical status and severity of white matter changes in symptomatic patients with subcortical small vessel disease.
Clinical neurology and neurosurgery - 1 Nov 2011
Pavlovic A M, Pekmezovic T, Obrenovic R, Novakovic I, Tomic G, Mijajlovic M, Sternic N
Abstract excerpt
OBJECTIVE: Elevated plasma total homocysteine (tHcy) is an independent risk factor for ischemic stroke and has been linked to cerebral small vessel disease (SVD), in particular. Controversy persists as to whether increased tHcy is associated with functional status and cognitive decline in these patients. METHODS: Plasma tHcy, MTHFR polymorphism, vascular risk factors, functional and cognitive status and severity...
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