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Article

Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction.

Brain : a journal of neurology - 1 Jan 2004

Hassan Ahamad, Hunt Beverley J, O'Sullivan Michael, Bell Rachel, D'Souza Reuben, Jeffery Steve, Bamford John M, Markus Hugh S

Abstract excerpt

Cerebral small vessel disease (SVD) causes focal lacunar infarction and more diffuse ischaemia, referred to as leukoaraiosis. Endothelial dysfunction has been proposed as a causal mechanism in the disease. Homocysteine is toxic to endothelium. We determined whether elevated homocysteine levels and the methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism are risk factors for SVD as a whole, and for two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14607791
DOI: 10.1093/brain/awh023

Genes

MTHFR
ICAM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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