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Article

Constitutional abnormalities of chromosome 21 predispose to iAMP21-acute lymphoblastic leukaemia.

European journal of medical genetics - 1 Mar 2016

Harrison Christine J, Schwab Claire

Abstract excerpt

In addition to Down syndrome, individuals with other constitutional abnormalities of chromosome 21 have an increased risk of developing childhood acute lymphoblastic leukaemia (ALL). Specifically, carriers of the Robertsonian translocation between chromosomes 15 and 21, rob(15;21) (q10; q10)c, have ∼2,700 increased risk of developing ALL with iAMP21 (intrachromosomal amplification of chromosome 21). In these...

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Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 15
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Share to Translocation, Genetic

Source

Identifiers

PMID: 26836400
DOI: 10.1016/j.ejmg.2016.01.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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