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Article

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia.

Blood - 23 Jun 2011

Rand Vikki, Parker Helen, Russell Lisa J, Schwab Claire, Ensor Hannah, Irving Julie, Jones Lisa, Masic Dino, Minto Lynne, Morrison Heather, Ryan Sarra, Robinson Hazel, Sinclair Paul, Moorman Anthony V, Strefford Jonathan C, Harrison Christine J

Abstract excerpt

Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct subgroup of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) that has a dismal outcome when treated with standard therapy. For improved diagnosis and risk stratification, the initiating genetic events need to be elucidated. To investigate the genetic basis of BCP-ALL, genomes of 94 iAMP21 patients were interrogated by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21527530
DOI: 10.1182/blood-2011-01-329961

Genes

CRLF2
ETV6
IKZF1
PAX5
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia.PMID 21527530Read ↗

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