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The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

22 May 2023

Abstract excerpt

Intrachromosomal amplification of chromosome 21 defines a subtype of high-risk childhood acute lymphoblastic leukemia (iAMP21-ALL) characterized by copy number changes and complex rearrangements of chromosome 21. The genomic basis of iAMP21-ALL and the pathogenic role of the region of amplification of chromosome 21 to leukemogenesis remains incompletely understood. In this study, using integrated whole genome and...

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Acute Lymphoblastic Leukemia research
Acute Myeloid Leukemia Research
Cancer Genomics and Diagnostics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37216686
DOI: 10.1182/blood.2022019094

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