Article
miR-34a inhibits the apoptosis of MDSCs by suppressing the expression of N-myc.
Immunology and cell biology - 1 Jul 2016
Chen Si, Huang Anfei, Chen Huo, Yang Yi, Xia Fei, Jin Liping, Zhang Jinping
Abstract excerpt
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors, which possess strong immunosuppressive functions. MDSCs are found in increased numbers in infectious and inflammatory pathological conditions. However, whether microRNAs have a role in the expansion remains unclear. Here in our study, we found that overexpression of miR-34a could induce the expansion of MDSCs in...
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