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Article

MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

1 Feb 2016

Abstract excerpt

Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activity via either chemical inhibitor or genetic ablation enhances VC. HDAC1 protein, but not mRNA, is reduced in cell and...

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PMID: 26832969
DOI: 10.1038/ncomms10492

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