Article
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype.
Nature genetics - 1 Nov 2019
Malhotra Rajeev, Mauer Andreas C, Lino Cardenas Christian L, Guo Xiuqing, Yao Jie, Zhang Xiaoling, Wunderer Florian, Smith Albert V, Wong Quenna, Pechlivanis Sonali, Hwang Shih-Jen, Wang Judy, Lu Lingyi, Nicholson Christopher J, Shelton Georgia, Buswell Mary D, Barnes Hanna J, Sigurslid Haakon H, Slocum Charles, Rourke Caitlin O', Rhee David K, Bagchi Aranya, Nigwekar Sagar U, Buys Emmanuel S, Campbell Catherine Y, Harris Tamara, Budoff Matthew, Criqui Michael H, Rotter Jerome I, Johnson Andrew D, Song Ci, Franceschini Nora, Debette Stephanie, Hoffmann Udo, Kälsch Hagen, Nöthen Markus M, Sigurdsson Sigurdur, Freedman Barry I, Bowden Donald W, Jöckel Karl-Heinz, Moebus Susanne, Erbel Raimund, Feitosa Mary F, Gudnason Vilmundur, Thanassoulis George, Zapol Warren M, Lindsay Mark E, Bloch Donald B, Post Wendy S, O'Donnell Christopher J
Abstract excerpt
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending thoracic aortic calcification (n = 8,422). Two genetic loci, HDAC9 and RAP1GAP, were associated with abdominal aortic calcification at a genome-wide level...
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